Immunobiology of Dendritic Cells in Inflammatory Bowel Disease

摘要: Breakdown of immunological tolerance toward the commensal microflora in genetically susceptible individuals is believed to be key event pathogenesis inflammatory bowel disease. Dendritic cells (DC) control critical balance between anergy and immunity due their functional dichotomy being either most potent antigen presenters or effective inducers (peripheral) tolerance. Due expression entire spectrum pattern recognition receptors (PRRs), such as toll-like (TLR) nucleotide-binding oligomerization domain NOD they can sense virtually all microbial-associated molecular patterns (MAMPs). This puts them a pivotal position for understanding distinct innate adaptive immune responses intestinal microbiota induce