An investigation of growth factors and lactoferrin in naturally occurring ovine pulmonary adenomatosis.

摘要: Ovine pulmonary adenomatosis (OPA), also known as jaagsiekte, is a transmissible beta retrovirus-induced lung tumour of sheep that has several features resembling human bronchoalveolar carcinoma (BAC). Angiogenesis been suggested to be one the most important factors underlying growth and invasion. This process involves action including vascular endothelial factor (VEGF)-C, basic fibroblast (bFGF), platelet-derived (PDGF)-C its receptor (PDGFR-α). Bovine lactoferrin (bLF), an iron heparin-binding glycoprotein secreted into various biological fluids, implicated in innate immunity anti-inflammatory anti-tumour functions. Tissues from 16 cases OPA were compared with tissues seven healthy control by immunohistochemistry. Expression markers was assessed semi-quantitatively ascribing immunoreactivity score (IRS) maximum value 300. VEGF-C, bFGF, PDGF-C, PDGFR-α bLF signals detected 10/16, 15/16, 12/16, 15/16 10/16 studied, respectively. expression weak neoplastic epithelial cells (IRS 21.4 ± 10.0) contrast high levels infiltrating macrophages plasma 141.3 ± 24.8 140.0 ± 25.1, respectively). The IRS elevated for (108.9 ± 18.2) lowest (20.4 ± 13.1 13.7 ± 12.4, These results suggest VEGF-C PDGF-C have roles pathogenesis OPA. may activate these lesions, but limited consequence defective or impaired function this molecule.