Prognostic value of co-expression of STAT3, mTOR and EGFR in gastric cancer.

摘要: Signal transducer and activator of transcription 3 (STAT3), the mammalian target rapamycin (mTOR) epidermal growth factor receptor (EGFR), proteins that mediate intracellular signaling related to cell growth, proliferation differentiation, have received considerable interest as possible targets for cancer treatment. We examined whether expression STAT3, mTOR EGFR correlates with clinicopathological features patient outcome in gastric cancer. Tumor samples were obtained from 126 patients adenocarcinomas who underwent a radical gastrectomy between 1999 2002. The phosphorylated STAT3 (p-STAT3), p-mTOR was analyzed by immunohistochemical staining. relations these factors outcomes assessed. p-STAT3 positively correlated following variables tumor progression: depth invasion (T1 vs. T2-4; p<0.001, p=0.036 respectively), lymph node involvement (p=0.008, p=0.027 p=0.007) stage (I II-IV; p=0.041 p<0.001). significantly distant metastasis recurrence (p=0.001 p=0.039), well poorer disease-specific survival (DSS; p=0.0018 p=0.026). marginally non-significant prognostic DSS (hazard ratio=2.0, 95% CI 0.91-4.5, p=0.082). Increasing p-STAT3, associated progressively worse DSS. Interactions among may play an important role progression