Erythroid differentiation regulator 1 (Erdr1) is a proapototic factor in human keratinocytes
作者： Hee Jung Kim , Seok Bean Song , Yoolhee Yang , Young Sun Eun , Baik Kee Cho
DOI: 10.1111/J.1600-0625.2011.01354.X
关键词: Biology 、 Apoptosis 、 Kinase 、 MAPK/ERK pathway 、 Human skin 、 Regulator 、 Protein kinase A 、 Cell biology 、 Cell culture 、 p38 mitogen-activated protein kinases
摘要: Skin is constantly exposed to physical and chemical stressors. The exposure of keratinocytes ultraviolet B (UVB) irradiation causes epidermal damage via induction apoptosis. Erythroid differentiation regulator 1 (Erdr1) modulates growth survival cells under various stressful conditions, but the function Erdr1 in human keratinocyte apoptosis has not been investigated so far. Here, we effect on UVB-induced also examined underlying regulatory mechanism. First, expression was detected primary normal skin tissues. Expression enhanced following UVB irradiation. Knock-down led resistance Also, overexpression increased induced caspase-3 activation. Furthermore, extracellular signal-regulated kinase (ERK) inhibitor PD98059 p38 mitogen-activated protein (MAPK) SB203580 significantly reduced These results indicate that induces a MAPK-dependent Taken together, these findings suggest role as proapoptotic factor acts ERK MAPK pathways. Therefore, may be potential therapeutic target reduce conditions such psoriasis cancer.
elsevier.com
sci-hub.se 参考文章(51)
A. Trautmann, M. Akdis, K. Blaser, C. A. Akdis, Role of dysregulated apoptosis in atopic dermatitis. Apoptosis. ,vol. 5, pp. 425- 429 ,(2000) , 10.1023/A:1009620329213
Diane F. Birt, Parviz Pour, David Mitchell, Heather Conway Pinch, Barry Gold, Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid Anticancer Research. ,vol. 17, pp. 85- 91 ,(1997)
Peter Dörmer, Elisabeth Spitzer, Marion Frankenberger, Elisabeth Kremmer, Erythroid differentiation regulator (EDR), a novel, highly conserved factor I. Induction of haemoglobin synthesis in erythroleukaemic cells. Cytokine. ,vol. 26, pp. 231- 242 ,(2004) , 10.1016/J.CYTO.2004.02.005
Brian J. Nickoloff, Rama Jasty, Valerie P. Castle, Craig B. Thompson, Raj S. Mitra, Tamara Wrone-Smith, Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin American Journal of Pathology. ,vol. 151, pp. 1321- 1329 ,(1997)
Trine Bertelsen, Lars Iversen, Jette Lindorff Riis, J. Simon C. Arthur, Bo Martin Bibby, Knud Kragballe, Claus Johansen, The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice. Experimental Dermatology. ,vol. 20, pp. 140- 145 ,(2011) , 10.1111/J.1600-0625.2010.01153.X
Kazuo Sutoh, Hiroshi Takatera, Hiroo Nakajima, Taisei Nomura, Kazuyasu Fukuda, Masayuki Kurooka, Li Ya Li, Takanori Kawaguchi, Eiji Taniguchi, Prakash M. Hande, Masato Ueda, Tadashi Hongyo, Induction of Cancer, Actinic Keratosis, and Specific p53 Mutations by UVB Light in Human Skin Maintained in Severe Combined Immunodeficient Mice Cancer Research. ,vol. 57, pp. 2081- 2084 ,(1997)
Shannon Reagan-Shaw, Jorien Breur, Nihal Ahmad, Enhancement of UVB radiation-mediated apoptosis by sanguinarine in HaCaT human immortalized keratinocytes. Molecular Cancer Therapeutics. ,vol. 5, pp. 418- 429 ,(2006) , 10.1158/1535-7163.MCT-05-0250
A M D'Costa, M F Denning, A caspase-resistant mutant of PKC-|[delta]| protects keratinocytes from UV-induced apoptosis Cell Death & Differentiation. ,vol. 12, pp. 224- 232 ,(2005) , 10.1038/SJ.CDD.4401558
Kun Park, Ji-Hye Lee, Photosensitizer effect of curcumin on UVB-irradiated HaCaT cells through activation of caspase pathways. Oncology Reports. ,vol. 17, pp. 537- 540 ,(2007) , 10.3892/OR.17.3.537
Leonid A. Sitailo, Shalini S. Tibudan, Mitchell F. Denning, Activation of Caspase-9 Is Required for UV-induced Apoptosis of Human Keratinocytes * Journal of Biological Chemistry. ,vol. 277, pp. 19346- 19352 ,(2002) , 10.1074/JBC.M200401200