Biologic markers in ductal carcinoma in situ and concurrent infiltrating carcinoma. A comparison of eight contemporary grading systems.
作者： Anthony S.-Y. Leong , Raija T. Sormunen , Songkhun Vinyuvat , Regina W. Hamdani , Cheepsumon Suthipintawong
DOI: 10.1309/WBU9-22QN-C3NA-2Q12
关键词: Dysplasia 、 Carcinoma in situ 、 Atypia 、 Carcinoma 、 Pathology 、 Medicine 、 Ductal carcinoma 、 Mammary gland 、 Biologic marker 、 Intraepithelial neoplasia
摘要: The relevance of 8 contemporary classification and grading systems for ductal carcinoma in situ (DCIS) the breast was examined 100 tumors by comparing DCIS grade with concurrent infiltrating (IDC). Besides tumor size nodal status, immunohistochemical parameters both lesions were compared, including estrogen receptor, progesterone c-erbB-2 protein, E-cadherin, vimentin, Ki-67 (MIB1), p27. Nuclear alone or combination architectural pattern necrosis showed best correlation invasive component. There also a positive between every biologic marker expressed IDC, supporting clonal relationship. Biologic markers varied different grades DCIS. is heterogeneous, progression to IDC may be from low-grade high-grade IDC. This concept conventional model held intraepithelial neoplasia cervix, vulva, vagina, skin, which there increasing severity atypia (dysplasia) before development stromal invasion.
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