Affinity of 5-thio-L-fucose-containing Lewis X (LeX) trisaccharide analogs to anti-LeX monoclonal antibody.
作者： Osamu Tsuruta , Hideya Yuasa , Hironobu Hashimoto , Sadamu Kurono , Shin Yazawa
DOI: 10.1016/S0960-894X(99)00124-9
关键词: Chemistry 、 Enzyme inhibitor 、 Chemical synthesis 、 Trisaccharide 、 Moiety 、 Biological activity 、 Fucose 、 Derivative (chemistry) 、 Glycoside 、 Stereochemistry
摘要: Abstract 5-Thiofucose-containing Le X trisaccharide analogs Galβ(1,4){5SFucα(1,3)}GlcNAc-OMe ( 2 ) and Galβ(1,4){5SFucβ(1,3)}GlcNAc-OMe 4 were synthesized via 5-thiofucosylation of methyl 2-azidolactoside derivative 6 by the trichloroacetimidate method. Inhibitory activity these for binding to anti-Le antibody was evaluated enzyme immunoassay, indicating that strictly recognizes α-configuration fucose moiety its pocket includes no advantageous region, such as hydrophobic area, recognizing ring sulfur atom 5-thiofucosyl analog .
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