Acute schizophrenia is accompanied by reduced T cell and increased B cell immunity

摘要: Previous studies of lymphocyte distribution in schizophrenia have yielded inconsistent results, as summarized the present study. Based on our own original data, potential confounds that might explain these variations are analyzed and discussed. Blood samples from 26 patients with acute paranoid were investigated comparison 32 matched healthy controls by flow cytometry (CD3, CD4, CD8, CD19, CD56 phenotyping). A subgroup drug-free was followed up after 6 weeks treatment. Cotinine levels free cortisol index (FCI) provided order to control for medication, smoking, stress. correlated natural killer (NK) cell counts (CD3−/CD56+: r = −0.383, P = 0.003) while FCI related B numbers (CD19+: r = 0.390, P = 0.003). Considering covariates, a lower level T helper cells (P = 0.010), reduced CD4/CD8 ratio (P = 0.029), elevated (P = 0.008) found during psychosis. After an inverse pattern observed initially patients: total (P = 0.005), (P = 0.003), suppressor/cytotoxic (P = 0.005) increased, declined (P = 0.049). In conclusion, may be accompanied defense shift towards immunity, which normalizes response addition disease stage or subtype cigarette smoking stress important co-factors.