Oxidant-Sensing Pathways in the Responses of Fungal Pathogens to Chemical Stress Signals.

摘要: Host defenses expose fungal pathogens to oxidants and antimicrobial chemicals. The cell employs conserved eukaryotic signaling pathways dedicated transcription factors program its response these stresses. oxidant-sensitive factor of yeast, YAP1, orthologs in filamentous fungi, are central tolerance oxidative stress. C-terminal domain YAP1 contains cysteine residues that, under oxidizing conditions, form an intramolecular disulfide bridge locking the molecule a conformation where nuclear export sequence is masked. accumulates nucleus, promoting genes that provide with ability counteract Chemicals including xenobiotics plant signals can also promote nuclearization yeast fungi. This could happen via direct or indirect stress, by different biochemical pathway. Plant phenolics known antioxidants, yet they have been shown elicit cellular responses would usually be triggered counter oxidant Here we will discuss evidence MAPK respond phenolic compounds. Following this other examples, explore here how oxidative-stress sensing networks fungi might evolved detect chemical stressors. Furthermore, draw functional parallels between mammalian Keap1/Nrf2 systems.