Gaps in Knowledge About the Association Between Maternal Periodontitis and Adverse Obstetric Outcomes: An Umbrella Review

摘要: Abstract Objectives Scientific literature has established that the periodontal condition during pregnancy could be associated with obstetric/neonatal morbidity, and these effects have an important relationship problems childhood cardiovascular disease in adulthood. This umbrella review aimed to summarize results about association between maternal periodontitis obstetric complications (low birth weight, preterm delivery, preeclampsia) identify gaps scientific literature. Methods An of systematic reviews or without meta-analysis was performed. Quality evaluation descriptive analysis characteristics included studies were conducted. Results Nineteen reviews/meta-analyses considered. In total, 99 observational studies. Most a higher risk low preeclampsia. The magnitude statistical significance this are influenced by context which been Gaps identified definition/evaluation disease, criteria gestational age for study purposes, potential confounders, among others. Conclusions Although analyzed pathologies, conceptual methodological identified, they should considered as integral components when is investigated.