Growth factors, endocrine aspects and hormonal treatment in hepatocellular carcinoma—an overview

摘要: Abstract Several clinical observations suggest that hepatocellular carcinoma (HCC or “hepatoma”) may be a hormone-dependent tumour; the apparent relation to anabolic steroids and oral contraceptive preparations, striking male predominance particularly among patients with cirrhosis. In many animal models thyroid hormones, prolactin testosterone stimulate tumour growth, latter enhance progression of chemically-induced hyperplastic nodules frank malignancy. animals humans, both oestrogen androgen receptors have been reported in normal malignant liver tissue though some evidence is conflicting amounts detected vary widely. From therapeutic standpoint, we failed show any advantage from addition tamoxifen adriamycin, controlled trial although other workers have, more recently, prolonged survival using alone. About 20% HCC receiving antiandrogen cyproterone acetate showed response.