Changes in liver lipidomics associated with sodium cholate-induced liver injury and its prevention by boiogito, a Japanese herbal medicine, in mice
作者： Shiro Watanabe , Kyosuke Fujita , Koichi Tsuneyama , Mitsuhiko Nose
DOI: 10.1002/TKM2.1032
关键词: Bile acid 、 Cholestasis 、 Liver X receptor 、 Fatty acid 、 Saturated fatty acid 、 Cholesterol 、 Endocrinology 、 Internal medicine 、 Liver injury 、 Chemistry 、 Lipidomics
摘要: Aim Bile acids play a crucial role in the development of cholestatic liver disease by mediating parenchymal cell injury and inflammation liver. Bile can also modulate lipid metabolism, although their pathogenesis diseases is mostly unknown. We examined effects boiogito (BOT), Japanese herbal medicine, on profile fractions mouse model sodium cholate (CA)-induced cholestasis. Methods Lipidomics was carried out to determine fatty acid composition triglycerides, cholesterol esters, total phospholipids using gas–liquid chromatography. Results CA induced differential changes The co-administration BOT CA attenuated triglycerides but not those esters phospholipids. Conclusion Lipidomics indicated unique property triglyceride association with preventive effect against CA-induced mice. plays an important hepatic TG metabolism via prevention cholestasis.
sci-hub.se 参考文章(24)
Katryn Allen, Hartmut Jaeschke, Bryan L. Copple, Bile Acids Induce Inflammatory Genes in Hepatocytes: A Novel Mechanism of Inflammation during Obstructive Cholestasis American Journal of Pathology. ,vol. 178, pp. 175- 186 ,(2011) , 10.1016/J.AJPATH.2010.11.026
James M. Ntambi, Young-Cheul Kim, Makoto Miyazaki, A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis Journal of Lipid Research. ,vol. 42, pp. 1018- 1024 ,(2001) , 10.1016/S0022-2275(20)31589-3
S Teng, M Piquette-Miller, Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis British Journal of Pharmacology. ,vol. 151, pp. 367- 376 ,(2007) , 10.1038/SJ.BJP.0707235
Mitsuhiro Watanabe, Sander M. Houten, Li Wang, Antonio Moschetta, David J. Mangelsdorf, Richard A. Heyman, David D. Moore, Johan Auwerx, Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. Journal of Clinical Investigation. ,vol. 113, pp. 1408- 1418 ,(2004) , 10.1172/JCI21025
Tarek Moustafa, Peter Fickert, Christoph Magnes, Christian Guelly, Andrea Thueringer, Sasa Frank, Dagmar Kratky, Wolfgang Sattler, Helga Reicher, Frank Sinner, Judith Gumhold, Dagmar Silbert, Günter Fauler, Gerald Höfler, Achim Lass, Rudolf Zechner, Michael Trauner, Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury Gastroenterology. ,vol. 142, pp. 140- 151 ,(2012) , 10.1053/J.GASTRO.2011.09.051
Shiro Watanabe, Koichi Tsuneyama, Eicosapentaenoic acid attenuates hepatic accumulation of cholesterol esters but aggravates liver injury and inflammation in mice fed a cholate-supplemented high-fat diet Journal of Toxicological Sciences. ,vol. 38, pp. 379- 390 ,(2013) , 10.2131/JTS.38.379
Eric Gumpricht, Rolf Dahl, Michael W. Devereaux, Ronald J. Sokol, Licorice Compounds Glycyrrhizin and 18β-Glycyrrhetinic Acid Are Potent Modulators of Bile Acid-induced Cytotoxicity in Rat Hepatocytes Journal of Biological Chemistry. ,vol. 280, pp. 10556- 10563 ,(2005) , 10.1074/JBC.M411673200
Tsutomu Shimada, Tomoko Akase, Mitsutaka Kosugi, Masaki Aburada, Preventive Effect of Boiogito on Metabolic Disorders in the TSOD Mouse, a Model of Spontaneous Obese Type II Diabetes Mellitus. Evidence-based Complementary and Alternative Medicine. ,vol. 2011, pp. 931073- 931073 ,(2011) , 10.1093/ECAM/NEP012
Toshiaki Teratani, Kengo Tomita, Takahiro Suzuki, Tetsuya Oshikawa, Hirokazu Yokoyama, Katsuyoshi Shimamura, Susumu Tominaga, Sadayuki Hiroi, Rie Irie, Yoshikiyo Okada, Chie Kurihara, Hirotoshi Ebinuma, Hidetsugu Saito, Ryota Hokari, Kazuo Sugiyama, Takanori Kanai, Soichiro Miura, Toshifumi Hibi, A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells Gastroenterology. ,vol. 142, pp. 152- 164 ,(2012) , 10.1053/J.GASTRO.2011.09.049
Yazen Alnouti, Iván L. Csanaky, Curtis D. Klaassen, Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC-MS/MS Journal of Chromatography B. ,vol. 873, pp. 209- 217 ,(2008) , 10.1016/J.JCHROMB.2008.08.018