Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis
作者： S Teng , M Piquette-Miller
关键词:
摘要: … PXR −/− mice to CA toxicity, we compared PXR −/− and PXR +/… that were significantly different between PXR +/+ and PXR −/− … 2- to 4-fold higher in PXR −/− mice than in PXR +/+ mice. In …
sci-hub.se 参考文章(38)
Hidetaka Akita, Hiroshi Suzuki, Tomoko Hirohashi, Hajime Takikawa, Yuichi Sugiyama, Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3 Pharmaceutical Research. ,vol. 19, pp. 34- 41 ,(2002) , 10.1023/A:1013699130991
T Laatikainen, E Ikonen, Serum bile acids in cholestasis of pregnancy. Obstetrics & Gynecology. ,vol. 50, pp. 313- 318 ,(1977)
Gernot Zollner, Peter Fickert, Andrea Fuchsbichler, Dagmar Silbert, Martin Wagner, Silvia Arbeiter, Frank J Gonzalez, Hanns-Ulrich Marschall, Kurt Zatloukal, Helmut Denk, Michael Trauner, Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine Journal of Hepatology. ,vol. 39, pp. 480- 488 ,(2003) , 10.1016/S0168-8278(03)00228-9
R Bossard, B Stieger, B O'Neill, G Fricker, P J Meier, Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver. Journal of Clinical Investigation. ,vol. 91, pp. 2714- 2720 ,(1993) , 10.1172/JCI116511
H. P. Hoensch, K. Balzer, P. Dylewizc, W. Kirch, H. Goebell, E. E. Ohnhaus, Effect of rifampicin treatment on hepatic drug metabolism and serum bile acids in patients with primary biliary cirrhosis. European Journal of Clinical Pharmacology. ,vol. 28, pp. 475- 477 ,(1985) , 10.1007/BF00544371
Simrat PS Saini, Ying Mu, Haibiao Gong, David Toma, Hirdesh Uppal, Songrong Ren, Song Li, Samuel M Poloyac, Wen Xie, None, Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice Hepatology. ,vol. 41, pp. 497- 505 ,(2005) , 10.1002/HEP.20570
Hanns-Ulrich Marschall, Martin Wagner, Karl Bodin, Gernot Zollner, Peter Fickert, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Jan Sjövall, Michael Trauner, Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids Journal of Lipid Research. ,vol. 47, pp. 582- 592 ,(2006) , 10.1194/JLR.M500427-JLR200
Shirley Teng, Micheline Piquette-Miller, The Involvement of the Pregnane X Receptor in Hepatic Gene Regulation during Inflammation in Mice Journal of Pharmacology and Experimental Therapeutics. ,vol. 312, pp. 841- 848 ,(2005) , 10.1124/JPET.104.076141
Martin Wagner, Peter Fickert, Gernot Zollner, Andrea Fuchsbichler, Dagmar Silbert, Oleksiy Tsybrovskyy, Kurt Zatloukal, Grace L. Guo, John D. Schuetz, Frank J. Gonzalez, Hanns-Ulrich Marschall, Helmut Denk, Michael Trauner, Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice Gastroenterology. ,vol. 125, pp. 825- 838 ,(2003) , 10.1016/S0016-5085(03)01068-0
Peter Fickert, Gernot Zollner, Andrea Fuchsbichler, Conny Stumptner, Christine Pojer, Rainer Zenz, Frank Lammert, Bruno Stieger, Peter J. Meier, Kurt Zatloukal, Helmut Denk, Michael Trauner, Effects of Ursodeoxycholic and Cholic Acid Feeding on Hepatocellular Transporter Expression in Mouse Liver Gastroenterology. ,vol. 121, pp. 170- 183 ,(2001) , 10.1053/GAST.2001.25542