A lysosome-targeted drug delivery system based on sorbitol backbone towards efficient cancer therapy.
作者： Santhi Maniganda , Vandana Sankar , Jyothi B. Nair , K. G. Raghu , Kaustabh K. Maiti
DOI: 10.1039/C4OB01153H
关键词: HeLa 、 Targeted drug delivery 、 Biochemistry 、 Cathepsin 、 Chemistry 、 Cathepsin B 、 Flow cytometry 、 MTT assay 、 Cytotoxicity 、 Drug delivery
摘要: A straightforward synthetic approach was adopted for the construction of a lysosome-targeted drug delivery system (TDDS) using sorbitol scaffold (Sor) linked to octa-guanidine and tetrapeptide GLPG, a peptide substrate of lysosomal cysteine protease, cathepsin B. The main objective was to efficiently deliver the potential anticancer drug, doxorubicin to the target sites, thereby minimizing dose-limiting toxicity. Three TDDS vectors were synthesized viz., DDS1: Sor-GLPG-Fl, DDS2: Sor-Fl (control) and DDS3: Sor-GLPGC-SMCC-Dox. Dox …
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