Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells

摘要: Objectives A growing number of epidemiological studies have demonstrated that the consumption green tea inhibits growth a variety cancers. Epigallocatechin gallate (EGCG), most abundant catechin in tea, has been shown to an anti-cancer effect against many Most cancers are believed be initiated from and maintained by small population tumor-initiating cells (TICs) responsible for chemotherapeutic resistance tumor relapse. In neuroblastoma, aggressive pediatric often relapses poor prognosis, TICs were recently identified as spheres grown serum-free non-adherent culture used neural crest stem cell growth. Although EGCG reported induce arrest apoptosis neuroblastoma cells, its on remains defined.