Clinicopathologic Analysis of Breast Cancers with PIK3CA Mutations in Japanese Women

摘要: Purpose: Somatic mutations of PIK3CA , which encodes the p110α catalytic subunit phosphatidylinositol 3-kinase, have recently been shown to play an important role in pathogenesis and progression human breast cancers. In this study, frequency their relationship with clinicopathologic biological variables were investigated Japanese Experimental Design: Mutational analysis was done 188 primary cancers women. Relationship these various [histologic type, tumor size, histologic grade, lymph node status, estrogen receptor (ER)-α progesterone prognosis], [phospho-AKT (pAKT) HER2 expression determined by immunohistochemistry], p53 mutation status studied. Results: Missense found 44 158 invasive ductal carcinomas, 4 10 lobular 1 mucinous 2 squamous apocrine but no 12 noninvasive carcinomas. -mutated tumors be more likely ER-α positive ( P status. significantly a significant Conclusions: The is similar that Caucasian Association pAKT suggests might exert effects through activation 3-kinase/AKT/ER-α pathway. seem potential used as indicator favorable prognosis.