PI3KCA mutation status is of limited prognostic relevance in ER-positive breast cancer patients treated with hormone therapy
作者： Lucia Veronica Cuorvo , Paolo Verderio , Chiara Maura Ciniselli , Salvatore Girlando , Nicola Decarli
DOI: 10.1007/S00428-013-1500-7
关键词: Univariate analysis 、 Hormone therapy 、 PI3K/AKT/mTOR pathway 、 Oncology 、 Breast cancer 、 Immunohistochemistry 、 PTEN 、 Protein kinase B 、 Estrogen receptor 、 Medicine 、 Internal medicine 、 Endocrinology 、 Pathology and Forensic Medicine 、 Cell biology 、 Molecular biology 、 General Medicine
摘要: PI3K/AKT/mTOR pathway alterations are frequent in patients with infiltrating breast cancer (IBC). Their clinical and pathological relevance has been insufficiently documented. We evaluated PI3KCA for mutations the expression of PTEN, AKT, mTOR p70S6K by immunohistochemistry 246 IBC treated hormone therapy (median follow-up, 97 months). A mutation was observed 50 out 229 informative cases (21.8 %), PTEN loss 107 210 (51 moderate/high level AKT 133 188 (71 173 218 (79 %) 111 192 (58 %). associated absence Her2/neu amplification/overexpression a low MIB1/Ki-67 labelling. The high immunoreactivity, level. Univariate analysis showed that status not outcome series as whole or node-negative subgroup. However, node-positive subgroup, exon 9 unfavourable overall survival (OS), although its impact on final model multivariate seemed to be limited. Of other markers, only significantly prolonged OS. is limited prognostic oestrogen receptor-positive therapy.
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