Prognostic role of PIK3CA mutations and their association with hormone receptor expression in breast cancer: a meta-analysis
作者： Bo Pang , Shi Cheng , Shi-Peng Sun , Cheng An , Zhi-Yuan Liu
DOI: 10.1038/SREP06255
关键词:
摘要: The phosphatidylinositol-4, 5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA) gene is frequently mutated in breast cancer (BCa). Sex hormone receptors (HRs), including estrogen receptor (ER) and progesterone (PR) play pivotal roles BCa. In this study, we evaluated the association between PIK3CA mutations ER/PR expression prognostic role of BCa patients, particular, HR-positive Thirty-two studies involving 5719 cases obtained from database searches were examined. correlated significantly with (p < 0.00001) relapse-free survival (RFS) (hazard ratio [HR] 0.76, 95% confidence interval [CI] 0.59–0.98, p = 0.03) but not overall (OS) (HR 1.14, 95%CI 0.72–1.82, 0.57) unsorted patients. associated OS 1.06, 0.67–1.67, 0.81) or RFS 0.86, 0.53–1.40, 0.55) conclusion, related to However, clinical implications may vary according different mutant exons. And alone have limited value for
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