Action of 1-β-d-Arabinofuranosylcytosine on mammalian tumor cells—2
作者： Werner E.G. Müller , Zen-I. Yamazaki , Heinz H. Sögtrop , Rudolf K. Zahn
DOI: 10.1016/0014-2964(72)90127-2
关键词: Biology 、 Neoplasm 、 Virus 、 Proliferating cell nuclear antigen 、 Enzyme 、 Murine leukemia virus 、 DNA 、 Molecular biology 、 RNA 、 DNA polymerase 、 General Medicine
摘要: Abstract 1. (1) 1 -β- d -Arabinofuranosylcytosinetriphosphate (ara-CTP) is an inhibitor of: DNA-dependent DNA polymerase from mammalian cells, RNA-dependent and Rauscher murine leukemia virus (RMLV) mouse lymphoma cells. 2. (2) All these inhibitions are of the competitive type. The polymerases oncogenic RNA viruses cells found to be most sensitive. These enzymes approximately 200 times as sensitive ara-CTP polymerases.
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