No Effect of Long-Term Risedronate Use on Cartilage and Subchondral Bone in an Experimental Rabbit Model of Osteoarthritis.

摘要: Osteoarthritis (OA) is the most prevalent degenerative joint disease in animals and humans. It characterized by pain, articular cartilage damage stiffness. has been suggested that status of subchondral bone compartment plays an important role initiation progression OA. Bisphosphonates have proposed as a potential disease-modifying treatment for OA, however their effectiveness not yet clear. Twenty-four male adult New Zealand rabbits were used to evaluate effects risedronate on quality degradation long-term model experimentally induced Animals underwent anterior cruciate ligament transection partial medial meniscectomy or sham operation only one knee, which was randomly chosen, using contralateral healthy control. divided into three groups (n = 8): untreated control group surgery group; both received vehicle; group, treated with 2.5 mg orally weekly 24 weeks. Stifle joints harvested scanned high-resolution micro-CT plate trabecular changes. The macroscopic evaluation histological analysis determined adapted Research Society International scoring scheme assess degeneration. lateral femoral condyle tibial plateau evaluated. Additionally, synovial membrane assessment carried out. Sample showed experimental osteoarthritic changes operated joints, whereas sham-operated rabbits, almost no observed surfaces. In terms analyses, risedronate-treated did show improved health compared but slightly anti-inflammatory activity membrane. Risedronate administration slight tendency increase thickness compartments but, it conservation periarticular be able suppress osteophyte formation. conclusion, use demonstrate positive effect reducing damage, failed prevent osteophytogenesis rabbit