Circadian blood pressure rhythm in patients with higher and lower spinal cord injury: simultaneous evaluation of autonomic nervous activity and physical activity.

摘要: Objective To examine the relationships among circadian rhythms of blood pressure, autonomic nervous function, and physical activity patients with varying levels spinal cord injury. Design methods We studied 19 injury [10 tetraplegic cervical (C4-C7), nine paraplegic thoracic (Th6-Th12)] compared 16 control subjects. A new multibiomedical recorder was used to measure pressure (every 30 min), cardiac vagal (hourly frequency R-R 50 ), (integrated acceleration/min) for 24 h under hospital conditions. Systemic sympathetic sympathoadrenal functioning were assessed by examination hormone in blood. Results Daytime night-time values compared; variations systolic diastolic pressures heart rate slight members tetraplegia group, but almost normal differences observed paraplegia group. The profile both patient groups, suggesting that an alteration rhythm had occurred patients. plasma norepinephrine level lower group than it (P<0.001), epinephrine (P< 0.05) (P<0.1) groups subjects 0.001 both). Conclusion central sympathoexcitatory pathway upper plays a critical role maintenance humans. Motor nerve secretion are not essential this regulation.