Pseudogenes as a paradigm of neutral evolution

作者: Wen-Hsiung Li , Takashi Gojobori , Masatoshi Nei

DOI: 10.1038/292237A0

关键词: Neutral mutationNucleotideGeneGeneticsSubstitution (logic)BiologyPseudogeneGlobinDNANeutral theory of molecular evolution

摘要: On the neutral mutation hypothesis1–3, rate of nucleotide substitution is expected to be higher for functionally less important genes or parts than more genes, as latter would subject stronger purifying (negative) selection2–4. other hand, selectionists believe that most substitutions are caused by positive darwinian selection5,6, in which case unimportant genes2,7 relatively lower because mutations these regions DNA not produce any significant selective advantages. Kimura8 and Jukes9 have argued observed at third positions codons first two supports hypothesis, third-position synonymous do change amino acids encoded, although others5,10 discussed possibility selection. Recently, Kimura11 noted mouse globin pseudogene, ψα3, evolved faster normal α1 gene, he did compute rate. Here, we present a method computing pseudogenes, report three recently discovered pseudogenes show an extremely high substitution. As apparently no function, this finding strongly hypothesis.

参考文章(21)
THOMAS H. JUKES, CHARLES R. CANTOR, CHAPTER 24 – Evolution of Protein Molecules Mammalian Protein Metabolism#R##N#Volume III. pp. 21- 132 ,(1969) , 10.1016/B978-1-4832-3211-9.50009-7
Hamish N. Monro, J. B. Allison, Mammalian Protein Metabolism ,(1969)
Francine Perler, Argiris Efstratiadis, Peter Lomedico, Walter Gilbert, Richard Kolodner, Jerry Dodgson, The evolution of genes: the chicken preproinsulin gene Cell. ,vol. 20, pp. 555- 566 ,(1980) , 10.1016/0092-8674(80)90641-8
T. Miyata, T. Yasunaga, Rapidly evolving mouse alpha-globin-related pseudo gene and its evolutionary history. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 450- 453 ,(1981) , 10.1073/PNAS.78.1.450
Jack L. King, Non-Darwinian Evolution Science. ,vol. 164, pp. 788- 798 ,(1969) , 10.1126/SCIENCE.164.3881.788
F. C. Kafatos, A. Efstratiadis, B. G. Forget, S. M. Weissman, Molecular evolution of human and rabbit beta-globin mRNAs. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 74, pp. 5618- 5622 ,(1977) , 10.1073/PNAS.74.12.5618
MOTOO KIMURA, Evolutionary Rate at the Molecular Level Nature. ,vol. 217, pp. 624- 626 ,(1968) , 10.1038/217624A0
THOMAS H. JUKES, JACK LESTER KING, Deleterious Mutations and Neutral Substitutions Nature. ,vol. 231, pp. 114- 115 ,(1971) , 10.1038/231114A0
Richard E. Dickerson, The structure of cytochromec and the rates of molecular evolution Journal of Molecular Evolution. ,vol. 1, pp. 26- 45 ,(1971) , 10.1007/BF01659392
Howard C. Heindell, Alvin Liu, Gary V. Paddock, Gary M. Studnicka, Winston A. Salser, The primary sequence of rabbit α-globin mRNA Cell. ,vol. 15, pp. 43- 54 ,(1978) , 10.1016/0092-8674(78)90081-8