作者: Wen-Hsiung Li , Takashi Gojobori , Masatoshi Nei
DOI: 10.1038/292237A0
关键词: Neutral mutation 、 Nucleotide 、 Gene 、 Genetics 、 Substitution (logic) 、 Biology 、 Pseudogene 、 Globin 、 DNA 、 Neutral theory of molecular evolution
摘要: On the neutral mutation hypothesis1–3, rate of nucleotide substitution is expected to be higher for functionally less important genes or parts than more genes, as latter would subject stronger purifying (negative) selection2–4. other hand, selectionists believe that most substitutions are caused by positive darwinian selection5,6, in which case unimportant genes2,7 relatively lower because mutations these regions DNA not produce any significant selective advantages. Kimura8 and Jukes9 have argued observed at third positions codons first two supports hypothesis, third-position synonymous do change amino acids encoded, although others5,10 discussed possibility selection. Recently, Kimura11 noted mouse globin pseudogene, ψα3, evolved faster normal α1 gene, he did compute rate. Here, we present a method computing pseudogenes, report three recently discovered pseudogenes show an extremely high substitution. As apparently no function, this finding strongly hypothesis.