An implantable drug-delivery system based on shape memory alloy micro-actuation

摘要: Abstract Shape memory alloy actuators feature an extremely high power-to-volume ratio. This property is a major advantage for miniature applications. paper describes implantable drug-delivery systems based on shape micro-actuation. A first type designed use with solid drugs while second design enables delivery of liquid drugs. The operating principle the latter system precisely controlled discontinuous release from pressurized reservoir. It realized using actuated microwave system. One dose can be accuracy up to 5 μl. remotely powered and transcutaneous transformer. refilling possibility injections provided. valve such that it mounted printed circuit board together other electrical components. Furthermore, optimized towards aspects like biocompatibility, low-cost production, lifetime, safety minimal dimensions. aiming at patients who need multiple each day over long period time. current prototype could already reduce number by factor 200. By further miniaturization reduction 3000 obtained.