A database of human genes and a gene network involved in response to tick-borne encephalitis virus infection

摘要: Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever severe neurological illness. Very little known about genetic factors predisposing forms disease TBEV. The aims study were compile catalog human genes involved in response and rank based on number neighbors network pairwise interactions involving these or proteins. Based manual review curation scientific publications comprising 140 was developed. To provide access data all genes, TBEVhostDB web resource ( http://icg.nsc.ru/TBEVHostDB/ ) created. We reconstructed formed between virion itself, viral proteins genes/proteins TBEVHostDB. Genes ranked according network. Two (CCR5 IFNAR1) that had maximal revealed. It found subnetworks CCR5 IFNAR1 their fragments two key pathways functioning during course encephalitis: (1) attenuation interferon-I signaling pathway NS5 protein targeted peptidase D; (2) proinflammation tissue damage triggered chemokine receptor interacting with CD4, CCL3, CCL4, CCL2. Among nine associated infection, three (CCR5, IL10, ARID1B) have protein-protein within network, (IFNL3 just mentioned) up- down-regulated infection. this finding, potential mechanisms for participation CCR5, ARID1B, IFNL3 host suggested. A database compiled TBEVHostDB resource, providing This first effort integrating unifying may predispose diseases could potentially be used assessment risk design personalized pharmacological strategies treatment