Molecular Mechanisms of Interaction Between Human Immune Cells and Far Eastern Tick-Borne Encephalitis Virus Strains
作者： Natalya V. Krylova , Tatiana P. Smolina , Galina N. Leonova
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摘要: Abstract Although studies have established that immune mechanisms are important in controlling tick-borne encephalitis virus (TBEV) infection, the interactions of different TBEV strains with cells innate and adaptive immunity not well understood. In this study, ability two Far Eastern subtype (Dal'negorsk Primorye-183) various degrees pathogenicity for humans to modulate expression membrane molecules differently on human were investigated using a whole-blood flow cytometry-based assay. The samples (from 10 healthy donors) infected analyzed binding blood cells, as adhesion (CD11b ICAM-1) activation (CD69, CD25, CD95) surfaces monocytes, granulocytes, natural killer (NK) T-lymphocytes (CD4+, CD8+) at selected times (3, 6, 24 h post-infection). It was found highly pathogenic Dal'negorsk strain penetrated rapidly wa...
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