Color vision impairment in Parkinson's disease.

摘要: Acquired disturbances of color vision are a highly varied group defects with frequent departures from established patterns. They can progress normal trichromatism to anomalous on dichromatic stage and monochromatism where most is lost, or they may be relatively stable [1]. A significant “modern effort” present such conditions was published for first time in 1972 [2], attention drawn account given 15 years later by Jaeger Krastel emphasizing pharmaco-therapeutical effects [3]. Normally, dopaminergic neurons act the outer inner retina at multiple levels, producing alterations flow visual information complex fashion. Dopamine chemical messenger light adaptation, promoting through cone circuits while diminishing that rod [4]. Color relies photoreceptor population therefore largely confined central retina. Because there segregation color-specific retinal into blue-yellow red-green pathways, it possible use discrimination tasks assess ganglion cell subpopulations It has been reported impaired Parkinson’s disease (PD) [5] some works have suggested these affect predominantly short-wave pathway [6]. Birch acquired type three (tritan) defect level as an early diagnostic sign ∗Correspondence to: Anna Piro, Neuroimaging Research Unit, IBFM-CNR, Germaneto, Catanzaro, Italy. Tel.: +393402529194; Fax: +39 0 9613695919; E-mail: anna.piro@cnr.it. [7]. We examined 49 PD Calabrian all male patients (age range, 50–85 years, mean age, 67 years) avoid genetic appearance “lionization” which heterozygous females deficiency who mimic [8]. All underwent L-DOPA doses subdivided two different groups: 125–300 mg/day, low daily dose; 400–1000 high dose. 25 age sex matched controls showing vision, comparison (chi square = 25.3, df 1, p< 0.0005) were enrolled 25/49 bleu/yellow axis. Controls did not show any signs, other ophthalmological disease. After informed consent, patients, had examination ophthalmologist order rule diabetic retinopathy, cataract, optic neuritis, senile maculopathy, ocular fundus’ anomalies could influence analysis. made more than 5 mistakes during their reading 17 Ishihara plates diagnosed being color-blind, this diagnosis confirmed next four (numbers 18–21) plates. The last 22–25) utilized define color-blindness (the red green colorbindness) grade color-blindness: protanopy, absence protanomaly, small deuteranopy, deuteranomaly, [9]. colorblind excluded So,