Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases.
作者： Luana G. Leal , Magno A. Lopes , Miguel L. Batista
关键词: Adipokine 、 Myokine 、 Skeletal muscle 、 Physical exercise 、 Proinflammatory cytokine 、 Adipose tissue 、 Bioinformatics 、 Medicine 、 Myostatin 、 Inflammation
摘要: Physical exercise has beneficial effects on metabolic diseases, and a combined therapeutic regimen of regular pharmaceutical treatment is often recommended for their clinical management. However, the mechanisms by which produces these are not fully understood. Myokines, group skeletal muscle (SkM) derived peptides may play an important part in this process. Myokines produced, expressed released fibers under contraction exert both local pleiotropic effects. such as IL-6, IL-10, IL-1ra during physical mediate its health benefits. Just seems to promote myokine response, inactivity impair it, could be mechanism explain association between sedentary behavior many chronic diseases. help configure immune-metabolic factor interface promoting through release humoral factors capable interacting with other tissues, mainly adipose tissue (AT). AT itself secretes proinflammatory cytokines (adipokines) result it well recognized that inflammation can lead development type 2 diabetes mellitus (T2DM) atherosclerosis. On hand, browning phenotype been suggested one improves body composition overweight/obese individuals. Although, involved crosstalk SkM AT, respect effects, IL-15, irisin, myostatin seem have decisive role "conversation" SkM. This review article proposes bring together latest "state art" knowledge regarding muscle-adipose crosstalk. Furthermore, intended particularly focus changes from directly mediated myokines.
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Christian P Fischer, Interleukin-6 in acute exercise and training: what is the biological relevance? Exercise Immunology Review. ,vol. 12, pp. 6- 33 ,(2006)
Hee-jae Kim, Byunghun So, Mijung Choi, Dongheon Kang, Wook Song, Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans Experimental Gerontology. ,vol. 70, pp. 11- 17 ,(2015) , 10.1016/J.EXGER.2015.07.006
Luis Gamas, Paulo Matafome, Raquel Seiça, Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications to Adipose Tissue: Muscle Crosstalk. Experimental Diabetes Research. ,vol. 2015, pp. 359159- 359159 ,(2015) , 10.1155/2015/359159
Anders Rinnov Nielsen, Remi Mounier, Peter Plomgaard, Ole Hartvig Mortensen, Milena Penkowa, Tobias Speerschneider, Henriette Pilegaard, Bente Klarlund Pedersen, Expression of interleukin-15 in human skeletal muscle – effect of exercise and muscle fibre type composition The Journal of Physiology. ,vol. 584, pp. 305- 312 ,(2007) , 10.1113/JPHYSIOL.2007.139618
B.K. Pedersen, A. Steensberg, C. Fischer, C. Keller, P. Keller, P. Plomgaard, M. Febbraio, B. Saltin, Searching for the exercise factor: is IL-6 a candidate? Journal of Muscle Research and Cell Motility. ,vol. 24, pp. 113- 119 ,(2003) , 10.1023/A:1026070911202
H Forouzanfar Mohammad, Afshin Ashkan, T Alexander Lily, H Ross Anderson, A Bhutta Zulfiqar, Biryukov Stan, Brauer Michael, Burnett Richard, Cercy Kelly, J Charlson Fiona, J Cohen Aaron, Dandona Lalit, Estep Kara, J Ferrari Alize, J Frostad Joseph, Fullman Nancy, W Gething Peter, W Godwin William, Griswold Max, Kinfu Yohannes, H Kyu Hmwe, J Larson Heidi, Liang Xiaofeng, S Lim Stephen, Y Liu Patrick, D Lopez Alan, Lozano Rafael, Marczak Laurie, A Mensah George, Mokdad Ali H, Moradi Lakeh Maziar, Naghavi Mohsen, Neal Bruce, B Reitsma Marissa, Roth Gregory A, A Salomon Joshua, J Sur Patrick, Vos Theo, Wagner Joseph A, Wang Haidong, Yi Zhao, Zhou Maigeng, Marit Aasvang Gunn, Alemu Abajobir Amanuel, Hassen Abate Kalkidan, Abbafati Cristiana, M Abbas Kaja, Abd Allah Foad, M Abdulle Abdishakur, Ferede Abera Semaw, Abraham Biju, J Laith, Yitayih Abyu Gebre, Olupelumi Adebiyi Akindele, Akinkunmi Adedeji Isaac, Ademi Zanfina, Kouablan Adou Arsène, C Adsuar José, Elisabet Agardh Emilie, Agarwal Arnav, Agrawal Anurag, Ahmad Kiadaliri Aliasghar, N Ajala Oluremi, F Akinyemiju Tomi, Al Aly Ziyad, Alam Khurshid, KM Noore, Fahed Aldhahri Saleh, William Aldridge Robert, Aderaw Alemu Zewdie, Ali Raghib, Alkerwi Ala'A, Alla François, Allebeck Peter, Alsharif Ubai, A Altirkawi Khalid, Alvarez Martin Elena, Alvis Guzman Nelson, T Amare Azmeraw, Amberbir Alemayehu, Kofi Amegah Adeladza, Amini Heresh, Ammar Walid, Marc Amrock Stephen, H Andersen Hjalte, O Anderson Benjamin, Abelardo T Antonio Carl, Anwari Palwasha, Ärnlöv Johan, Al Artaman, Asayesh Hamid, Jawad Asghar Rana, Assadi Reza, Atique Suleman, Frinel G Euripide, Awasthi Ashish, Paulina Ayala Quintanilla Beatriz, Azzopardi Peter, Bacha Umar, Badawi Alaa, Bahit Maria C, Balakrishnan Kalpana, Barac Aleksandra, M Barber Ryan, L Suzanne, Bärnighausen Till, Barquera Simon, Barregard Lars, Barrero Lope H, Basu Sanjay, Batis Carolina, Bazargan Hejazi Shahrzad, Beardsley Justin, Bedi Neeraj, Beghi Ettore, L Bell Michelle, K Bello Aminu, A Bennett Derrick, M Bensenor Isabela, Berhane Adugnaw, Bernabé Eduardo, Demtsu Betsu Balem, Shunu Beyene Addisu, Bhala Neeraj, Bhansali Anil, Bhatt Samir, Biadgilign Sibhatu, Bikbov Boris, Bisanzio Donal, Bjertness Espen, D Blore Jed, Borschmann Rohan, Boufous Soufiane, RA Rupert, Brainin Michael, Brazinova Alexandra, JK Nicholas, Brenner Hermann, Broday David M, S Brugha Traolach, Brunekreef Bert, A Butt Zahid, E Cahill Leah, Calabria Bianca, Ricardo Campos Nonato Ismael, Cárdenas Rosario, Carpenter David O, Casey Daniel C, Castañeda Orjuela Carlos A, Castillo Rivas Jacqueline, None, Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 The Lancet. ,vol. 388, pp. 1659- 1724 ,(2016) , 10.1016/S0140-6736(16)31679-8
Shingo Kajimura, Bruce M. Spiegelman, Patrick Seale, Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metabolism. ,vol. 22, pp. 546- 559 ,(2015) , 10.1016/J.CMET.2015.09.007
REBECCA E. K. MACPHERSON, JASON S. HUBER, SCOTT FRENDO-CUMBO, JEREMY A. SIMPSON, DAVID C. WRIGHT, Adipose Tissue Insulin Action and IL-6 Signaling after Exercise in Obese Mice Medicine and Science in Sports and Exercise. ,vol. 47, pp. 2034- 2042 ,(2015) , 10.1249/MSS.0000000000000660
D. L. Williamson, P. M. Gallagher, C. C. Carroll, U. Raue, S. W. Trappe, Reduction in hybrid single muscle fiber proportions with resistance training in humans. Journal of Applied Physiology. ,vol. 91, pp. 1955- 1961 ,(2001) , 10.1152/JAPPL.2001.91.5.1955
Bente K. Pedersen, Muscle as a secretory organ. Comprehensive Physiology. ,vol. 3, pp. 1337- 1362 ,(2013) , 10.1002/CPHY.C120033