Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.
作者： Tobias Karlberg , Marie-France Langelier , John M. Pascal , Herwig Schüler
DOI: 10.1016/J.MAM.2013.02.002
关键词: Protein degradation 、 Cell biology 、 Chromatin 、 Effector 、 Biology 、 Organelle assembly 、 Small molecule 、 Structural biology 、 Macro domain 、 DNA repair
摘要: ADP-ribosylation of proteins regulates protein activities in various processes including transcription control, chromatin organization, organelle assembly, degradation, and DNA repair. Modulating the involved metabolism can have therapeutic benefits disease states. Protein crystal structures help understand biological functions, facilitate detailed analysis single residues, as well provide a basis for development small molecule effectors. Here we review recent advances our understanding structural biology writers, readers, erasers ADP-ribosylation.
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