Branching of poly(ADP-ribose): Synthesis of the Core Motif.
作者： Hans A. V. Kistemaker , Herman S. Overkleeft , Gijsbert A. van der Marel , Dmitri V. Filippov
DOI: 10.1021/ACS.ORGLETT.5B02143
关键词:
摘要: The synthesis of the core motif branched poly(adenosine diphosphate ribose) (poly(ADPr)) is described, and structural analysis reasserted proposed stereochemistry for branching. For synthesis, a ribose trisaccharide was first constructed with only α-O-glycosidic linkages. Finally, adenine nucleobase introduced via Vorbruggen-type glycosylation reaction. orthogonality selected protecting groups demonstrated, allowing construction poly(ADPr) oligomers in near future.
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