Solid‐Phase Synthesis of Oligo‐ADP‐Ribose
作者： Hans A.V. Kistemaker , Nico J. Meeuwenoord , Herman S. Overkleeft , Gijsbert A. Marel , Dmitri V. Filippov
DOI: 10.1002/0471142700.NC0468S64
关键词:
摘要: Solid-phase methodology for synthesis of adenosine diphosphate ribose oligomers (ADPr-oligomers) defined length is described using an advanced 2-ribosyl phosphoramidite building block that prepared in solution via expeditious and high-yielding method. The based on phosphitylation a phosphomonoester as the key condensation step solid-phase protocol. As ADP-ribosylation appears to be important yet poorly understood post-translational modification proteins, presented rapid ADPr-fragments exactly should interest researchers field structural biology cell biology. © 2016 by John Wiley & Sons, Inc. Keywords: solid-phase synthesis; poly(ADP-ribose); phosphorylation; pyrophosphate
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