Intense arousal of novel male mice in proximity to previously inseminated females: Inactivation of males via chlorpromazine does not diminish the capacity to disrupt pregnancy

摘要: In the course of investigating early pregnancy disruptions by novel males, intense behavioral interactions and chemical emissions were observed among males housed in proximity to inseminated females. These evident despite wire-mesh separations between Experiments designed examine whether such arousal plays a role disruption. During first 5 days pregnancy, CF-1 strain female mice either left undisturbed or exposed outbred males. Physical did not diminish frequency Subsequently, we investigated heavy sedation via chronic chlorpromazine administration would capacity disrupt pregnancy. Pregnancy was disrupted same degree females drug-treated those alert competing given vehicle injections. data show an unprecedented pheromonal emission but suggest that these factors are critical for