Eicosapentaenoic acid at hypotriglyceridemic dose enhances the hepatic antioxidant defense in mice.

摘要: The effect of oral administration purified (95%) eicosapentaenoic acid on serum lipids, hepatic peroxisomal enzymes, antioxidant enzymes and lipid peroxidation was compared with that palmitic fed mice corresponding controls. After 10 d, a dose 1000 mg per day/kg body weight lowered triglycerides by 45%, while no significant change in cholesterol level noted comparison to Hepatic acyl-CoA oxidase catalase activities increased 50% 30%, respectively, the group. In addition, reduced glutathione content transferase, peroxidase reductase, significantly during treatment. levels peroxides were lower after feeding, when Taken together, present data demonstrate for first time at hypolipidemic doses feeding i) enhances defense, ii) does not cause differential induction two catalase, as peroxisome proliferating compounds, such clofibrate rodents.