Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst
作者： Tristan Frum , Michael A. Halbisen , Chaoyang Wang , Hossein Amiri , Paul Robson
DOI: 10.1016/J.DEVCEL.2013.05.004
关键词: Epiblast 、 Nanog Homeobox Protein 、 Regulation of gene expression 、 Biology 、 Endoderm 、 Molecular biology 、 Embryo 、 Embryonic stem cell 、 FGF4 、 Blastocyst
摘要: In embryonic stem (ES) cells and in early mouse embryos, the transcription factor Oct4 is an essential regulator of pluripotency. transcriptional targets have been described ES cell lines; however, molecular mechanisms by which regulates establishment pluripotency epiblast (EPI) not fully elucidated. Here, we show that neither maternal nor zygotic required for formation EPI blastocyst. Rather, first development primitive endoderm (PE), extraembryonic lineage. promote PE fate neighboring secreting Fgf4, expression but promotes cell-autonomously, downstream Fgf4 Mapk. Finally, multiple genes as well metabolic pathways continued growth preimplantation embryo.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(60)
Hitoshi Niwa, Jun-ichi Miyazaki, Austin G. Smith, Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genetics. ,vol. 24, pp. 372- 376 ,(2000) , 10.1038/74199
Masami Kanai-Azuma, Masamichi Kurohmaru, Patrick P. L. Tam, Choji Taya, Yoshiakira Kanai, Youichi Tajima, Kazumori Yazaki, Yoshihiro Hayashi, Yutaka Sanai, Hiromichi Yonekawa, Jacqueline M. Gad, Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. ,vol. 129, pp. 2367- 2379 ,(2002) , 10.1242/DEV.129.10.2367
Nicolas Plachta, Tobias Bollenbach, Shirley Pease, Scott E. Fraser, Periklis Pantazis, Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nature Cell Biology. ,vol. 13, pp. 117- 123 ,(2011) , 10.1038/NCB2154
A. Ralston, B. J. Cox, N. Nishioka, H. Sasaki, E. Chea, P. Rugg-Gunn, G. Guo, P. Robson, J. S. Draper, J. Rossant, Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2 Development. ,vol. 137, pp. 395- 403 ,(2010) , 10.1242/DEV.038828
Natalia Ivanova, Radu Dobrin, Rong Lu, Iulia Kotenko, John Levorse, Christina DeCoste, Xenia Schafer, Yi Lun, Ihor R. Lemischka, Dissecting self-renewal in stem cells with RNA interference Nature. ,vol. 442, pp. 533- 538 ,(2006) , 10.1038/NATURE04915
Satoshi Tanaka, Tilo Kunath, Anna-Katerina Hadjantonakis, Andras Nagy, Janet Rossant, Promotion of Trophoblast Stem Cell Proliferation by FGF4 Science. ,vol. 282, pp. 2072- 2075 ,(1998) , 10.1126/SCIENCE.282.5396.2072
Mitchell H. Rosner, M. Alessandra Vigano, Keiko Ozato, Paula M. Timmons, Francoise Poirie, Peter W. J. Rigby, Louis M. Staudt, A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. ,vol. 345, pp. 686- 692 ,(1990) , 10.1038/345686A0
Jennifer Nichols, Branko Zevnik, Konstantinos Anastassiadis, Hitoshi Niwa, Daniela Klewe-Nebenius, Ian Chambers, Hans Schöler, Austin Smith, Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 Cell. ,vol. 95, pp. 379- 391 ,(1998) , 10.1016/S0092-8674(00)81769-9
Guoji Guo, Mikael Huss, Guo Qing Tong, Chaoyang Wang, Li Li Sun, Neil D. Clarke, Paul Robson, Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst Developmental Cell. ,vol. 18, pp. 675- 685 ,(2010) , 10.1016/J.DEVCEL.2010.02.012
Daniel M. Messerschmidt, Rolf Kemler, Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism Developmental Biology. ,vol. 344, pp. 129- 137 ,(2010) , 10.1016/J.YDBIO.2010.04.020