Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2
作者： A. Ralston , B. J. Cox , N. Nishioka , H. Sasaki , E. Chea
DOI: 10.1242/DEV.038828
关键词:
摘要: The mouse blastocyst and stem cells derived from its tissue lineages provide a unique genetic system for examining the establishment loss of pluripotency. transcription factor Cdx2 plays central role by repressing pluripotency genes, such as Oct4, promoting extraembryonic trophoblast fate at stage. However, evidence has suggested that does not work alone in lineage. We have used bioinformatic functional genomic strategies to identify Gata3 factor. show be capable inducing embryonic driving differentiation cells. In addition, is required Gata3-induced expression subset genes coexpressed with blastocyst, but this depend on Cdx2. embryo, Gata3, like Cdx2, depends Tead4, both factors becomes restricted mechanism initially rely Oct4. These observations suggest can act parallel pathways downstream Tead4 induce common independent targets lineage, whereas Oct4 continued repression
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