Effects of reperfusion after coronary artery occlusion on post-infarction scar tissue.
作者： C M Connelly , W M Vogel , A W Wiegner , E L Osmers , O H Bing
关键词: Myocardial infarction 、 Pathology 、 Hydroxyproline 、 Medicine 、 Lagomorpha 、 Internal medicine 、 Ultimate tensile strength 、 Coronary occlusion 、 Myocyte 、 Occlusion 、 Scars 、 Cardiology
摘要: Early reperfusion after a coronary occlusion may reduce myocardial infarct size, but late into necrotic myocardium alter post-infarction healing. In rabbits, we compared 1- or 3-week-old scars resulting from permanent to those 3-hour followed by reperfusion. Reperfusion at 1 hour post-occlusion did not affect scar mechanical properties assessed week post-infarction, 3 weeks these had tensile strength significantly lower than reperfused (78 +/- 11 vs. 158 15 g/mm2, P less 0.001). They also were composed of mixture fibrous tissue (58 8%) and myocytes (43 with hydroxyproline content 23 2.5 mg/g dry weight. The nonreperfused higher proportion (73 3%) histological evaluation 35% (31 2 weight, 0.001) the hour. contrast, "late" hours similar in composition content. Nonetheless, was that (72 5 associated collagen cross-link density this group scars. At physiological stress levels (approximately g/mm2), all groups terms natural strain, stiffness, creep, relaxation. Thus, although ruptured more easily high stresses, when stresses their different
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