Sex-related differences in morphine's antinociceptive activity: relationship to serum and brain morphine concentrations.
作者： Theodore J. Cicero , Edward R. Meyer , Bruce Nock
DOI:
关键词: Morphine 、 Alfentanil 、 Central nervous system 、 Pharmacology 、 Sex related 、 Agonist 、 ED50 、 Nociception 、 Pharmacokinetics 、 Medicine
摘要: In earlier studies, it was shown that male rats were considerably more sensitive to the antinociceptive properties of morphine than females in several assays. The purpose our studies examine whether these male-female differences might be due blood and brain levels attained after its s.c. injection rather intrinsic central nervous system sensitivity drug. Our results confirmed males on hot-plate test; ED50 approximately half found females. These sex not unique because also potent mu agonist, alfentanil. With respect pharmacokinetics morphine, we there a linear relationship both between dose injected achieved 60 min when sex-linked morphine-induced antinociception greatest; no peak or at any morphine. Furthermore, elimination half-life from and, similarly, disappearance brain. On basis data, appears sex-related have observed response morphine’s activity cannot explained by Rather, are related inherent
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