Sex specificity in methadone analgesia in the rat: a population pharmacokinetic and pharmacodynamic approach.
作者： Monica Rodriguez , M. Angeles Carlos , Ignacio Ortega , Elena Suarez , Rosario Calvo
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摘要: Purpose. To quantify the extent to which a sex-specific dichotomy in temporal evolution of analgesic effect, after intravenous (i.v.) methadone injection rat, relates pharmacokinetics (PK) and pharmacodynamics (PD) that mediate dose-to-effect pathway.
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