Complete Bordetella avium, Bordetella hinzii and Bordetella trematum lipid A structures and genomic sequence analyses of the loci involved in their modifications.

作者: Alexey Novikov , Nita R Shah , Sami AlBitar-Nehme , Soorej M Basheer , Ilaria Trento

DOI: 10.1177/1753425913506950

关键词: Lipid AMicrobiologyBordetella aviumBordetella hinziiBordetella trematumVirulencePathogenBiologyBordetellaHuman pathogen

摘要: Endotoxin is recognized as one of the virulence factors Bordetella avium bird pathogen, and characterization its structure corresponding genomic features are important for an understanding role in pathogenicity improved general knowledge spp factors. The biologically active part B. LPS, lipid A, described compared to those another opportunistic humans, hinzii, that trematum, a human pathogen. Sequence analyses showed three strains have homologues acyl-chain modifying enzymes PagL, PagP LpxO, 1-phosphatase LpxE, addition LgmA, LgmB LgmC, which required glucosamine modification. MALDI mass spectrometry identified high amount substituting phosphate groups A; this modification was absent from hinzii trematum. acylation patterns As were similar, but they d...

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