Coping with loss of perfection in the MHC class I peptide repertoire

摘要: The MHC class I molecules present thousands of peptides (pMHC I) on the cell surface for immune surveillance by CD8 T cells. pMHC repertoire normally contains perfect length and sequences suitable binding each I. are made first fragmenting cytoplasmic proteins. fragments then transported into endoplasmic reticulum (ER), where they trimmed to appropriate ER aminopeptidase associated with antigen processing (ERAAP) generate final Here, we review studies role ERAAP in generating from endogenous or viral proteins their ability elicit responses. absence profoundly disrupts which can have major consequences responses antigens.