UCS1025A and B, new antitumor antibiotics from the fungus Acremonium species.
作者： Tsutomu Agatsuma , Tsutomu Akama , Shinji Nara , Shigeki Matsumiya , Ryuichiro Nakai
DOI: 10.1021/OL026923B
关键词: Cell culture 、 Fungus 、 Antimicrobial 、 Acremonium sp 、 Antitumor Antibiotics 、 Chemistry 、 Tautomer 、 Stereochemistry 、 Human tumor 、 Acremonium species
摘要: UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were isolated from the fungus Acremonium sp. KY4917. The structures stereochemistry elucidated by a combination of two-dimensional NMR X-ray crystallographic analysis. showed unique chemical equilibria involving three tautomeric isomers exhibited antimicrobial activity antiproliferative against human tumor cell lines.
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sci-hub.se 参考文章(7)
Karine Auclair, Andrew Sutherland, Jonathan Kennedy, David J. Witter, Johan P. Van den Heever, C. Richard Hutchinson, John C. Vederas, Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue Journal of the American Chemical Society. ,vol. 122, pp. 11519- 11520 ,(2000) , 10.1021/JA003216+
Eufrocinio C Marfori, Takeshi Bamba, Shin 'ichiro Kajiyama, Ei-ichiro Fukusaki, Akio Kobayashi, Biosynthetic studies of the tetramic acid antibiotic trichosetin Tetrahedron. ,vol. 58, pp. 6655- 6658 ,(2002) , 10.1016/S0040-4020(02)00689-0
Bryan H. Norman, Jonathan Paschal, Chris J. Vlahos, Synthetic studies on the furan ring of wortmannin Bioorganic & Medicinal Chemistry Letters. ,vol. 5, pp. 1183- 1186 ,(1995) , 10.1016/0960-894X(95)00191-U
RYUICHIRO NAKAI, HARUMI OGAWA, AKIRA ASAI, KATSUHIKO ANDO, TSUTOMU AGAISUMA, SHIGEKI MAISUMIYA, SHIRO AKINAGA, YOSHINORI YAMASHITA, TAMIO MIZUKAMI, UCS1025A, a novel antibiotic produced by Acremonium sp. The Journal of Antibiotics. ,vol. 53, pp. 294- 296 ,(2000) , 10.7164/ANTIBIOTICS.53.294
Shohei Suzuki, Tomoo Hosoe, Koohei Nozawa, Ken-ichi Kawai, Takashi Yaguchi, Shun-ichi Udagawa, Antifungal Substances Against Pathogenic Fungi, Talaroconvolutins, from Talaromyces convolutus Journal of Natural Products. ,vol. 63, pp. 768- 772 ,(2000) , 10.1021/NP990371X
Masaji Kasai, Motomichi Kono, Shunichi Ikeda, Nobuyuki Yoda, Noriaki Hirayama, An efficient chemical conversion of mitomycin A to isomitomycin A Journal of Organic Chemistry. ,vol. 57, pp. 7296- 7299 ,(1992) , 10.1021/JO00052A052
Hideaki Oikawa, Tomonori Kobayashi, Kinya Katayama, Yuichi Suzuki, Akitami Ichihara, Total Synthesis of (−)-Solanapyrone A via Enzymatic Diels−Alder Reaction of Prosolanapyrone Journal of Organic Chemistry. ,vol. 63, pp. 8748- 8756 ,(1998) , 10.1021/JO980743R