Expressão gênica e proteica das isoformas A e B do receptor de progesterona, de p53 e de p21 em miométrio e leiomioma uterino

摘要: Leiomyomas are common benign neoplasms of the female reproductive system and they found in up to 50% women age. The causes mechanisms development this tumor not well established. Occasional lack control apoptotic pathways influences ovarian steroid hormones must be involved. aim study was examine expression gene protein progesterone receptor isoforms A B, p53 p21 uterine leiomyoma myometrium. Samples 14 reproductive-age patients, submitted abdominal hysterectomy due leiomyomatosis, were obtained. tissues mRNA extraction using Trizol for analysis through RT-PCR technique, developed Western blot technique. There significant differences levels PRAB, PRB PRs between myometrium leiomyoma. It any correlation menstrual cycle phase receptors. relationship (PRA: PRB) different it observed a strong (r = 0.767, P 0.004) them. showed an increase when compared (P 0.030 0.002). same 0.016) 0.026) samples unchanged expressions characteristic diseases such as alterations PRA: malignant neoplasms. However, leiomyomas indicates possible participation those genes that tumor, which can related functional stabilization retention damage, avoiding carcinogenic transformation.