Smoking Is Associated with Acute and Chronic Prostatic Inflammation: Results from the REDUCE Study.

摘要: Both anti- and proinflammatory effects of cigarette smoking have been described. As prostate inflammation is common, we hypothesized could contribute to inflammation. Thus, evaluated the association status with acute chronic within men undergoing biopsy. We retrospectively analyzed 8,190 ages 50 75 years PSA levels between 2.5 10 ng/mL enrolled in Reduction by Dutasteride Prostate Cancer Events study. Smoking was self-defined as never, former, or current. assessed systematic central review blinded status. The baseline, 2-year, 4-year biopsies univariable multivariable logistic regressions. At study enrollment, 1,233 (15%), 3,203 (39%), 3,754 (46%) were current, never smokers, respectively. Current smokers significantly younger had smaller prostates than former (all P < 0.05). Former heavier current ( 0.001). Acute inflammations identified 1,261 (15%) 6,352 (78%) baseline biopsies, In analysis, more likely (OR, 1.35; , 0.001) 1.36; results unchanged at 2- biopsies. contrast, linked biopsy, but not conclusion, among independently associated possibly inflammations. Prev Res; 8(4); 312–7. ©2015 AACR .