Baseline prostate inflammation is associated with a reduced risk of prostate cancer in men undergoing repeat prostate biopsy: Results from the REDUCE study

摘要: BACKGROUND The current study was performed to evaluate whether baseline acute and chronic prostate inflammation among men with an initial negative biopsy for cancer (PCa) increased the risk of subsequent PCa detection in a clinical trial systematic biopsies. METHODS A retrospective analysis 6238 aged 50 years 75 prostate-specific antigen levels between 2.5 ng/mL 10 prior REduction by DUtasteride Events who completed 2-year biopsy. PCa, inflammation, were assessed central review. The association biopsies positive 4-year repeat evaluated chi-square test logistic regression adjusting covariates. RESULTS Acute both detected 46 (1%), 3931 (63%), 892 (14%), respectively. Acute found be significantly associated each other (P < .001). at younger age, lower levels, smaller (all P < .01), whereas older age larger glands P < 0.01). At biopsy, prevalence 14% (N = 900 patients). On univariable multivariable analysis, (acute univariable: odds ratio [OR], 0.65 [P < .001] multivariable: OR, 0.75 [P = .012] 0.61 [P < .001]). time only risk. CONCLUSIONS Baseline independently risk. From standpoint, may detection. Cancer 2014;120:190–196. © 2013 American Society.