Nanostructured indium tin oxide slides for small-molecule profiling and imaging mass spectrometry of metabolites by surface-assisted laser desorption ionization MS.
作者： Carlos López de Laorden , Ana Beloqui , Luis Yate , Javier Calvo , Maria Puigivila
DOI: 10.1021/AC5025864
关键词: Sputter deposition 、 Analytical chemistry 、 Ellipsometry 、 Mass spectrometry imaging 、 Thin film 、 Scanning electron microscope 、 Substrate (electronics) 、 Surface-assisted laser desorption/ionization 、 Chemistry 、 Indium tin oxide
摘要: Due to their electrical conductivity and optical transparency, slides coated with a thin layer of indium tin oxide (ITO) are the standard substrate for protein imaging mass spectrometry on tissue samples by MALDI-TOF MS. We have now studied rf magnetron sputtering deposition parameters prepare ITO films glass substrates required nanometric surface structure use in matrix-free metabolites small-molecule drugs, without affecting transparency classical histology. The custom-made surfaces were characterized atomic force microscopy, scanning electron ellipsometry, UV, laser desorption ionization MS (LDI-MS) employed LDI-MS-based analysis glycans druglike molecules, quantification lactose milk isotopic dilution, metabolite mouse brain samples.
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