Glycan-targeted drug delivery for intravesical therapy: in the footsteps of uropathogenic bacteria
作者： Lukas Neutsch , Franz Gabor , Michael Wirth
DOI: 10.4155/TDE.14.25
关键词: Drug uptake 、 Glycan 、 Bladder cavity 、 Urothelium 、 Cancer research 、 Intravesical route 、 Surgery 、 Biology 、 Targeted drug delivery 、 Bladder cancer 、 Drug administration 、 Pharmaceutical Science
摘要: The human urothelium belongs to the most efficient biobarriers, and represents a highly rewarding but challenging target for local drug administration. Inadequate urothelial bioavailability is major obstacle successful treatment of bladder cancer other diseases, yet little research has addressed development advanced delivery concepts intravesical route. A prominent example how overcome barrier by means specific biorecognition cytoinvasion UPEC bacteria, mediated mannose-targeted lectin domain FimH. Similar mechanisms non-bacterial origin may be exploited enhancing uptake from cavity. This review covers current status in lectin-based strategies urinary tract. Different preparing optimizing carbohydrate-targeted systems are presented, along with important design parameters, benefits shortcomings. Bioconjugate- nano-/microparticle-based ...
future-science.com
sci-hub.se 参考文章(90)
Claus‐Michael Lehr, Joke A. Bouwstra, Wouter Kok, Arthur B. J. Noach, Albertus G. de Boer, Hans E. Junginger, Bioadhesion by means of specific binding of tomato lectin. Pharmaceutical Research. ,vol. 9, pp. 547- 553 ,(1992) , 10.1023/A:1015804816582
A Mrhar, M Bogataj, M Kerec Kos, Mucoadhesion on urinary bladder mucosa: the influence of sodium, calcium, and magnesium ions. Die Pharmazie. ,vol. 65, pp. 505- 509 ,(2010)
Peter Pietzonka, Barbara Rothen‐Rutishauser, Peter Langguth, Heidi Wunderli‐Allenspach, Elke Walter, Hans P. Merkle, Transfer of lipophilic markers from PLGA and polystyrene nanoparticles to caco-2 monolayers mimics particle uptake. Pharmaceutical Research. ,vol. 19, pp. 595- 601 ,(2002) , 10.1023/A:1015393710253
Michael Wirth, Andrea Fuchs, Michaela Wolf, Bernhard Ertl, Franz Gabor, Lectin-mediated drug targeting: preparation, binding characteristics, and antiproliferative activity of wheat germ agglutinin conjugated doxorubicin on Caco-2 cells. Pharmaceutical Research. ,vol. 15, pp. 1031- 1037 ,(1998) , 10.1023/A:1011926026653
T. R. L. Griffiths, , Current perspectives in bladder cancer management. International Journal of Clinical Practice. ,vol. 67, pp. 435- 448 ,(2013) , 10.1111/IJCP.12075
Claus-Michael Lehr, Lectin-mediated drug delivery: the second generation of bioadhesives. Journal of Controlled Release. ,vol. 65, pp. 19- 29 ,(2000) , 10.1016/S0168-3659(99)00228-X
Yair Lotan, Ashish M. Kamat, Michael P. Porter, Victoria L. Robinson, Neal Shore, Michael Jewett, Paul F. Schelhammer, Ralph deVere White, Diane Quale, Cheryl T. Lee, , Key concerns about the current state of bladder cancer: a position paper from the Bladder Cancer Think Tank, the Bladder Cancer Advocacy Network, and the Society of Urologic Oncology. Cancer. ,vol. 115, pp. 4096- 4103 ,(2009) , 10.1002/CNCR.24463
Tina Leakakos, Cheng Ji, Greg Lawson, Caryn Peterson, Scott Goodwin, Intravesical administration of doxorubicin to swine bladder using magnetically targeted carriers. Cancer Chemotherapy and Pharmacology. ,vol. 51, pp. 445- 450 ,(2003) , 10.1007/S00280-003-0597-9
L. K. Trejdosiewicz, K. A. R. Hutton, J. Southgate, D. F. M. Thomas, Normal human urothelial cells in vitro: proliferation and induction of stratification. Laboratory Investigation. ,vol. 71, pp. 583- 594 ,(1994)
Torben F. Ørntoft, Peter Meldgaard, Eric P. Bennett, Hans Wolf, Eric H. Holmes, Henrik Clausen, Jesper Zeuthen, Blood group ABO-related glycosylation of urothelial cell lines: immunocytological, enzymatic, and genetic characterization. Cancer Research. ,vol. 54, pp. 2440- 2447 ,(1994)