Complexation of the antihypertensive drug oxprenolol with copper(II)
作者： Panayot R Bontchev , Ivayla N Pantcheva , Todor Todorov , Dimitar R Mehandjiev , Nikolay S Savov
DOI: 10.1016/S0162-0134(00)00126-4
关键词: Crystallography 、 Magnetic susceptibility 、 Oxygen 、 Methanol 、 Crystal structure 、 Inorganic chemistry 、 Electron paramagnetic resonance 、 Oxprenolol 、 Copper 、 Ligand 、 Chemistry
摘要: Abstract The complexation between copper(II) and the antihypertensive drug oxprenolol (HOxp) was studied both in methanol slightly alkaline aqueous media at Cu:HOxp molar ratio from 1:1 to 1:10. Copper(II) forms two types of complexes–a mononuclear violet one, CuOxp 2 , with bidentately bound ligands a green dimeric Cu Oxp Cl which Cu(II) centres are linked by ligand through oxygen bridges. crystal structure complex consists crystallographically non-equivalent centrosymmetric copper dimers. Each atom is four-coordinated distorted square-planar environment. O structural core characterized Cu1–O1–Cu1′ angle 104.15(13)° (Cu2–O2–Cu2′ 104.30(13)°) relatively short Cu1–Cu1′ separation 3.026(1) A (Cu2–Cu2′−3.023(1) A). Magnetic susceptibility EPR measurements indicate an antiferromagnetic coupling centers.
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