Overexpression of TELO2 decreases survival in human high-grade gliomas
作者： Shao-Wei Feng , Ying Chen , Wen-Chiuan Tsai , Hsin-Ying Clair Chiou , Sheng-Tang Wu
DOI: 10.18632/ONCOTARGET.10021
关键词: Immunostaining 、 Pathology 、 Hazard ratio 、 Medicine 、 Tissue microarray 、 Cancer research 、 Messenger RNA 、 Biomarker (medicine) 、 Western blot 、 Glioma 、 Immunohistochemistry
摘要: High-grade gliomas are characterized with poor prognosis. To improve the clinical outcome, biomarker is urgently needed for distinguishing oncotarget in high-grade gliomas. Telomere maintenance 2 (TELO2) regulates S-phase checkpoint cell cycle, and involved DNA repair. However, role of TELO2 survival outcome still not yet clarified. This study aims to investigate correlation between mRNA expression patients Based on bioinformatics study, we found that Kaplan-Meier analysis demonstrated shorter higher levels than those lower (median survival, 59 vs. 113 weeks, p=0.0017, by log-rank test, hazard ratio: 0.3505, 95% CI: 01824.-0.6735). significantly World Health Organization (WHO) grade IV non-tumor control (p=2.85 x 10-9). Moreover, level was greater WHO III controls (p= 0.017) human We further validated protein using quantitative RT-PCR, Western blot, immunohistochemical (IHC) stain tissue microarray. Consistently, were elevated glioma cells comparison normal brain control. Additionally, IHC staining showed immunostain score low-grade gliomas, or Taken together, increase expression, overexpression correlates supporting an
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