A Stabilizing Influence: CAL PDZ Inhibition Extends the Half‐Life of ΔF508‐CFTR
作者： Patrick R. Cushing , Lars Vouilleme , Maria Pellegrini , Prisca Boisguerin , Dean R. Madden
关键词: PDZ domain 、 Cell 、 Chloride channel 、 Membrane protein 、 Protein–protein interaction 、 Ion channel 、 Cell biology 、 Biochemistry 、 Cystic fibrosis 、 Chemistry 、 Cystic fibrosis transmembrane conductance regulator
摘要: From synthesis to degradation, membrane proteins navigate interwoven networks that control their localization and activity within the cell. At branchpoints these networks, protein-protein interactions often determine flux of individual through specific pathways thus offer targets for therapeutic modulation. The PDZ (PSD-95, Dlg, ZO-1) constitute a major family trafficking regulators. Characterized by presence eponymous interaction domains (PPIDs), generally bind C-termini partners help choreograph movements throughout regulation include cystic fibrosis transmembrane conductance regulator (CFTR), chloride channel mutated in patients with (CF)[1].
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