Inhibition of PDZ domain-mediated interactions.

摘要: Modulating protein-protein interactions constitutes a promising strategy both for the investigation of biological mechanisms and developing new therapeutic approaches. Among many types inter-actions, PDZ domain-mediated (PDMIs) have emerged over last decade as attractive targets in drug discovery field. Indeed, these small domains are involved regulation signaling pathways possess structural properties which favorable design competing ligands. Herein, we describe recent approaches developed to inhibit this class interactions.