Prevention of the Neurotoxicity of the Amyloid β Protein by Genipin
作者： Matsumi YAMAZAKI , Naoki SAKURA , Kenzo CHIBA , Tetsuro MOHRI
DOI: 10.1248/BPB.24.1454
关键词: Toxicity 、 Biology 、 Lactate dehydrogenase 、 Hippocampal formation 、 Biochemistry 、 Pharmacology 、 Neurotoxin 、 Neuroprotection 、 Genipin 、 Neuron 、 Neurotoxicity
摘要: Genipin, which was shown in our previous investigation to have prominent neuritogenic activity paraneurons such as PC12h cells, studied determine whether it could prevent the toxicity of Alzheimer’s amyloid β protein (Aβ) cultured hippocampal neurons. Increased release lactate dehydrogenase from neurons after 2 d Aβ25-35 administration prevented dose dependently by addition genipin 20—40 μM. Morphological observations and trypan blue staining cells confirmed protection Aβ genipin. Geniposide had less effect preventing toxicity.
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