Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

作者: T. L. M. Hectors , C. Vanparys , K. van der Ven , G. A. Martens , P. G. Jorens

DOI: 10.1007/S00125-011-2109-5

关键词: PollutantDiabetes mellitusInsulinPopulationEndocrine disruptorGenetic predispositionType 2 diabetesImmunologyBeta (finance)Biology

摘要: The prevalence of diabetes mellitus is currently at epidemic proportions and it estimated that will increase even further over the next decades. Although genetic predisposition lifestyle choices are commonly accepted reasons for occurrence type 2 diabetes, has recently been suggested environmental pollutants additional risk factors development this review aims to give an overview current evidence this. More specifically, because crucial role pancreatic beta cells in progression present work summarises known effects several compounds on cell function with reference mechanistic studies have elucidated how these interfere insulin secreting capacity cells. Oestrogenic compounds, organophosphorus persistent organic heavy metals discussed, a critical reflection relevance concentrations used relative levels found human population given. It clear some affect function, as both epidemiological experimental research accumulating. This supports need develop solid structured platform fully explore diabetes-inducing potential pollutants.

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